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The mechanisms behind this upregulation appear to involve: Activation of the Nrf2 pathway, which controls the expression of various antioxidant enzymes including GR Modulation of cellular signaling cascades that respond to redox status Alteration of mitochondrial metabolism, influencing NADPH availability for GR activity Reduction of inflammatory signaling that can suppress antioxidant enzyme expression These effects suggest that hydrogen water may provide a "hormetic" stimulusa mild oxidative challenge that triggers beneficial adaptive responses in cellular antioxidant systems

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

Iron-chelating and ros-scavenging polymers with thioketal and thioether bonds delivering ferroptosis inhibitor lip-1 provide a triple therapeutic strategy for retina ganglion cells in acute glaucoma

13 (8), e13901s

Biogerontology 24 , 125

World Journal of Gastrointestinal Pathophysiology